Reiss Nelson came on in the 62nd minute and scored his second Hoffenheim goal in the 80th minute as his loan side lost 2-1 to Eintracht Frankurt.
Takuma Asano started but went off injured after 14 minutes as Hannover beat Stuttgart 3-1.
David Ospina played the whole game and kept a clean sheet as Napoli beat Sassuolo 2-0.
Matt Macey played 90 minutes and kept a clean sheet as Plymouth Argyle beat AFC Wimbledon 1-0.
Krystian Bielik was an unused substitute as Charlton Athletic lost 2-1 to Coventry City.
Kelechi Nwakali wasn’t involved as Porto B lost 1-0 to Arouca.
Calum Chambers wasn’t permitted to feature as Fulham lost 5-1 to Arsenal.