Lucas Perez was deployed up front and played the whole game as Deportivo La Coruna lost 1-0 to Atletico Madrid.
Takuma Asano started on the right wing and played the full game as Stuttgart lost 3-1 to Hamburg.
Kelechi Nwakali started and played 59 minutes as VVV-Venlo drew 0-0 with NAC Breda.
Emiliano Martinez was an un-used substitute as Getafe drew 2-2 with Real Betis. Joel Campbell missed out for Betis due to injury.
Marc Bola was an un-used substitute as Bristol Rovers lost 4-2 against his former loan club Notts County in the FA Cup.
Stephy Mavididi was an un-used substitute as Preston North End lost 3-0 to Ipswich Town.
Cohen Bramall wasn’t involved and Carl Jenkinson missed out through injury as Birmingham City lost 2-0 to Barnsley.