Takuma Asano started and played 65 minutes as Stuttgart lost 1-0 to RB Leipzig.
Joel Campbell played 62 minutes as Real Betis beat Deportivo La Coruna 2-0, with Lucas Perez not involved for the visitors.
Stephy Mavididi came on in the 61st minute of Preston North End’s 3-2 loss against Wolverhampton Wanderers.
Kelechi Nwakali was brought in the 86th minute as VVV-Venlo lost 2-0 to ADO Den Haag.
Emiliano Martinez was an unused substitute as Getafe drew 1-1 with Levante.
Cohen Bramall wasn’t involved and Carl Jenkinson missed out through injury as Birmingham City lost 2-0 to Millwall.
Marc Bola was an unused substitute as Bristol Rovers were beaten 1-0 by Rochdale.